In this webinar, we will explore molecule design for Targeted Protein Degradation and demonstrate how software solutions Spark™ and Flare™ can help overcome some of the challenges and streamline the design of degraders and linkers. By attending the webinar, you will learn how to:

• Modify your existing linkers with Spark’s scaffold hopping experiment and Flare’s Hit Expander module
• Find novel linkers with Spark’s ligand joining experiment
• Create custom Spark linker libraries with Flare
• Synthesize your complexes with Flare’s Library Enumeration feature
• Dock to binary protein complexes and assess their fit to the protein binding sites
• Use Flare’s unique Electrostatic Complementarity™ feature to visually and numerically assess the complementarity to the binding sites in the protein complex