Find novel chemistries through innovative scaffold hopping and bioisosteric replacement
Customers say Spark is the best scaffold hopping software they have ever used. Spark can match the nature of your molecules better than any other tool by working in electrostatic and shape space. In this way, you can generate diverse, non-obvious bioisostere ideas for your drug discovery projects starting from fragments of real molecules.
Try Spark™ for yourself
Chemical creativity starts here
With Spark, you can find the freedom to operate even in congested IP spaces, avoiding patent-related issues or expanding your own IP. Spark accelerates lead optimization and reduces the risk of late-stage attrition by finding replacements of functional groups that are important for binding, but problematic in terms of ADMET properties.
Generate highly innovative ideas for your project
Escape IP and ADMET traps
Find the freedom to operate even in congested IP spaces, avoiding patent-related issues or expanding your own IP
Reduce the risk of late-stage attrition
Accelerate lead optimization and reduce the risk of late-stage attrition by finding replacements of functional groups that are important for binding, but problematic in terms of ADMET properties
