Rapidly explore millions of commercially available compounds
Blaze is Cresset’s ligand-based virtual screening platform. Blaze uses the electrostatics and shape of a query ligand to rapidly search large chemical collections for molecules with similar 3D properties. Blaze results typically include a high diversity of hits, with hit rates as high as 30%.
With a virtual screen of 10 million structures taking just a few hours, Blaze enables huge time and cost savings, significantly reducing the number of compounds to purchase and test. Only the best quality leads are sent to the lab, making early-stage drug discovery more cost-effective, and reducing the environmental impact caused by wasted chemicals.
Through our virtual screening web server, Blaze Cloud, we offer a fast and flexible solution, using a secure, encrypted web browser session.
Seamless access to Blaze from Flare™, Cresset’s CADD platform, facilitates the preparation of experiments and the visualization and post-processing of results.
- Increase the diversity of your project’s leads and back-ups
- Jump into new areas of chemical space
- Find novel lead-like hits from known actives
- Replace peptides with non-peptides or steroids with non-steroids
- Achieve substantial improvements in the properties of your hits
- Fast search algorithm – a virtual screen of 10 million structures takes just a few hours
