Case study Addressing metabolic liabilities by bioisosteric replacements with Spark™Anand Balupuri†, Giovanna Tedesco† †Cresset, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire, SG8 0SS, UK Abstract Metabolic...
Case study Discovering a Novel Therapy for Urinary Tract Infections Through Outsourcing In-silico Drug DiscoveryResearch from the University of Cambridge highlights the inhibition of an E. coli enzyme as a plausible route to reduce pathogenicity and increase...
Case study Finding new leads from peptides and natural ligandsChinese Stuart Firth-Clark† †Cresset, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire, SG8 0SS, UK The key to designing...
Case study Investigating the SAR of RIPK1 inhibitorsChinese Sylvie Sciammetta† †Cresset, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire, SG8 0SS, UK Abstract Understanding...
Case study Streamlining design for covalent inhibitorsNathan Kidley† †Cresset, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire, SG8 0SS, UK Abstract Medicinal chemistry has...
Case study Pick new ligand-protein interactions from the active site with Spark™日本語で読む In this case study we will use the new Spark docking feature of the Cresset bioisostere replacement and scaffold hopping tool to prioritize...
Case study 3D-QSAR study on JAK inhibitors日本語で読む Nathan Kidley† † Cresset, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire, SG8 0SS, UK Abstract Robust and predictive...
Case study Find a chemical starting pointMany customers engage Cresset Discovery to find a chemical starting point for their project. The input could be a competitor compound, a peptide,...
Case study Innovative 3D clustering method created to deliver diverse fragment librariesBioBlocks needed to build a fragment library with maximum coverage of 3D chemical space. As part of the project, we developed an innovative clustering...
