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Method filter: Hit Expander

Compound idea generation
Compound idea generation is the process of designing new molecular structures likely to bind a biological target, using structural insights,...
Hit Expander
Rapidly step through the hit-to-lead process with minimal expenditure on wet-chemistry
Improving properties of heterobifunctional degraders via single-point changes to linkers
What are heterobifunctional degrader molecules and how do they work? Heterobifunctional degraders utilized in Targeted Protein Degradation...
Rapid approaches to new scaffold generation accelerate hit-to-lead
Using Hit Expander and QSAR to design and score new ligands in silico
Hit Expander: A new method to rapidly assess and step through the hit-to-lead process with minimal expenditure on wet-chemistry
You may have seen a recent paper by Yuan Hu and Ingo Mügge from Alkermes on ‘In Silico Positional Analogue Scanning with Amber GPU-TI’. The idea behind...