Flare™ V11 released
We are excited to announce the release of Flare V11 introducing powerful new scientific capabilities, faster workflows, and enhanced usability, giving you the tools to explore complex systems with greater efficiency and accuracy.
From new generative chemistry tools, improved Free Energy Perturbation (FEP) workflows and enhanced Protein-Protein Docking capabilities to smarter ligand management and more flexible calculation handling, this release addresses key challenges faced by researchers working with complex molecular systems.
Product Manager Sofia Bariami walks through the latest updates in Flare.
Accelerating optimization of METTL3 inhibitor
Cresset’s Discovery team has delivered a highly efficient digital workflow combining their molecular modeling expertise with Cresset technology to accelerate discovery, design and optimization of a METTL3 inhibitor. Working with Epics Therapeutics, the workflow combines scaffold hopping, in silico design and prioritization together with Epic’s medicinal chemistry team to drive efficient hit discovery and optimization, enabling progression towards a drug development candidate. Read more…
Work smarter and faster with the Flare AI Assistant
New in the latest version of Flare is the AI Assistant, designed to make working with Flare both faster and easier. The assistant comes with a Chat and a Code model. If you missed the webinar, watch on demand and experience a walk-through demonstration to see how the AI Assistant improves task efficiency and reduces barriers for users with varying levels of programming experience. Learn best practices for interacting with Flare’s AI assistants to maximise your productivity.
Don’t miss Cresset’s February in-person workshop in Cambridge, MA – A Hit to Lead Workflow: Using Spark and Flare Guide to Compound Design
Looking ahead to next year, we are delighted to be hosting an in-person workshop at CIC Cambridge Broadway on 18 February 2026. Join us for an insightful live demonstration based on a study of Tankyrase-1 to learn how Cresset’s Spark™ and Flare™ desktop applications work synergistically to accelerate and refine drug discovery projects. The workshop will give you the hands-on experience to fine-tune your work and design the molecules that matter, while also enjoying the chance to network with fellow scientists and industry professionals.
Season’s greetings from Cresset
Another year draws to a close very shortly. How was 2025 for you? For Cresset we achieved major milestones including a significant technology acquisition, our first release of AI functionality, major improvements in our CADD platform Flare™, and we have, with the help of customers, been revisiting our mission and vision for the future.
Read more from Cresset’s CEO Tim Cheeseright in his end of year message.
See us at upcoming conferences, exhibitions & events
Cresset are due to attend, exhibit and/or present at the following events. Further information can be found via our upcoming events schedule.
Modeling for Chemical and Biological (Re)Activity (MCBR) 2025
Hyderabad, India I 11-14 December
A Hit to Lead workflow: Using Spark and Flare to Guide Compound Design
Cambridge, USA I 18 February
BMCS 3rd Conformational Design in Drug Discovery 2026
Stevenage, UK I 2 March
AI in Drug Discovery 2026
London, UK I 9-10 March
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