Virtual screening is a cost-effective approach to complement, replace, and increase efficiency of ‘wet’ screening, allowing the exploration of a larger chemical space, the discovery of more diverse chemotypes and the generation of new IP in the search for novel hits.
Cresset’s proprietary ligand-based virtual screening platform Blaze™ uses the electrostatics and shape of a query ligand to rapidly search large chemical collections for molecules with similar 3D properties, unbiased by substructure and chemotype similarity.
Blaze results typically include a large diversity of novel lead-like structures, with hit rates as high as 30%.
The screening databases available from the Cresset Blaze server contain more than 30 million commercial compounds easily accessible from vendor databases.
