For all those biological targets where experimental information about the protein structure is unavailable (for example, many GPCRs, ion channels and novel targets), Homology Modeling is the best way to create a reliable 3D structure to use for structure-based studies.
Homology Modeling in Flare is powered by ProMod3.
- Connect to a secure homology modeling server hosted by Cresset
- Build reliable homology models starting from aligned target sequences and template chains with sequence identity as low as 30%
- Generate robust homology models in just a few minutes
- Build single chain or multi-chain models
- Build apo- and liganded proteins
- Use single or multiple templates
References and acknowledgements
G. Studer, G. Tauriello, S. Bienert, M. Biasini, N. Johner and T. Schwede, ProMod3—A versatile homology modelling toolbox, PLOS Comput. Biol. 2021, 17, e1008667.